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Doxorubicin-<a href=

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9920

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19

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67

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179

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59

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887

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2960

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44

Isotope-Labeled Compounds

608

Antibodies

8

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-116063
    Doxorubicin-SMCC

    		Drug-Linker Conjugates for ADC Cancer
    Doxorubicin-SMCC is a agent-linker conjugate for ADC. Doxorubicin-SMCC contains a non-cleavable ADC linker and a DNA topoisomerase II inhibitor Doxorubicin .
    <em>Doxorubicin</em>-SMCC
  • HY-15142
    Doxorubicin hydrochloride
    360+ Cited Publications

    Hydroxydaunorubicin hydrochloride

    		 Topoisomerase ADC Cytotoxin AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Infection Cancer
    Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .
    <em>Doxorubicin</em> hydrochloride
  • HY-152965
    Biotin-doxorubicin

    		Topoisomerase Antibiotic Apoptosis Autophagy Infection Cancer
    Biotin-doxorubicin is a Biotin-labeled Doxorubicin. Doxorubicin, a broad-spectrum anthracycline antibiotic, is a topoisomerase II inhibitor .
    Biotin-<em>doxorubicin</em>
  • HY-15142A
    Doxorubicin

    Hydroxydaunorubicin

    		 ADC Cytotoxin Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV Infection Cancer
    Doxorubicin (Hydroxydaunorubicin), a broad-spectrum anthracycline antibiotic with cytotoxic properties, is an anti-cancer chemotherapy agent. Doxorubicin has fluorescence properties. Doxorubicin inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy . Doxorubicin inhibits human DNA topoisomerase I with an IC50 of 0.8 μM .
    <em>Doxorubicin</em>
  • HY-16532
    Zoptarelin doxorubicin

    AEZS-108; AN-152

    		 GnRH Receptor Cancer
    Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro .
    Zoptarelin <em>doxorubicin</em>
  • HY-141158
    N-(Iodoacetamido)-Doxorubicin

    		ADC Linker Cancer
    N-(Iodoacetamido)-Doxorubicin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    N-(Iodoacetamido)-<em>Doxorubicin</em>
  • HY-136288
    Azide-PEG4-VC-PAB-Doxorubicin

    		Drug-Linker Conjugates for ADC Cancer
    Azide-PEG4-VC-PAB-Doxorubicin is a agent-linker conjugate composed of a cytotoxic anthracycline antibiotic Doxorubicin and a linker Azide-PEG4-VC-PAB to make antibody agent conjugate (ADC) . Azide-PEG4-VC-PAB-Doxorubicin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Azide-PEG4-VC-PAB-<em>Doxorubicin</em>
  • HY-15142AS1
    Doxorubicin-13C,d3 TFA

    Hydroxydaunorubicin-13C,d3 TFA

    		 Isotope-Labeled Compounds Antibiotic Endogenous Metabolite Infection Cancer
    Doxorubicin- 13C,d3 (TFA) is the deuterium and 13C labeled Doxorubicin. Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin inhibits topoisomerase II with an IC50 of 2.67 μM, thus stoppin
    <em>Doxorubicin</em>-13C,d3 TFA
  • HY-16261A
    MC-DOXHZN

    (E/Z)-AlDoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone

    		 Topoisomerase Drug-Linker Conjugates for ADC Cancer
    MC-DOXHZN ((E/Z)-Aldoxorubicin) is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), with acid-sensitive properties .
    MC-DOXHZN
  • HY-16261B
    MC-DOXHZN hydrochloride
    5 Publications Verification

    (E/Z)-AlDoxorubicin hydrochloride; Doxorubicin(6-maleimidocaproyl)hydrazone hydrochloride

    		 Topoisomerase Drug-Linker Conjugates for ADC Cancer
    MC-DOXHZN ((E/Z)-Aldoxorubicin) hydrochloride is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), with acid-sensitive properties .
    MC-DOXHZN hydrochloride
  • HY-15794
    Nemorubicin

    Methoxymorpholinyl Doxorubicin; FCE 23762; PNU 152243

    		 G-quadruplex Cancer
    Nemorubicin (Methoxymorpholinyl doxorubicin) is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity .
    Nemorubicin
  • HY-15794G
    Nemorubicin

    Methoxymorpholinyl Doxorubicin; FCE 23762; PNU 152243

    		 G-quadruplex Cancer
    Nemorubicin (Methoxymorpholinyl doxorubicin) GMP is a GMP-class Nemorubicin (HY-15794). Nemorubicin is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity .
    Nemorubicin
  • HY-121309S
    Doxorubicinone-d3

    Adriamycin aglycone-d3; Adriamycinone-d3

    		 Endogenous Metabolite Cancer
    Doxorubicinone-d3 is the deuterium labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin[1]. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.
    Doxorubicinone-d3
  • HY-13745
    Sabarubicin

    MEN 10755

    		 Topoisomerase Cancer
    Sabarubicin is a doxorubicin disaccharide analogue with striking antitumor activity. Sabarubicin is more effective than doxorubicin as a topoisomerase II poison and stimulated DNA fragmentation at lower intracellular concentrations.
    Sabarubicin
  • HY-153797
    Dox-btn2

    		ADC Cytotoxin Antibiotic Bacterial Topoisomerase AMPK HIV HBV Apoptosis Autophagy Mitophagy Infection Cancer
    Dox-btn2 is a biotinylated derivative of Doxorubicin (HY-15142A), with a biotin label at the point of conjugation to doxorubicin at 3'-NH2. Dox-btn2 can be used for cell imaging. While Doxorubicin is mainly accumulated in the nucleus, while Dox-btn2 is mainly located in the cytoplasm .
    Dox-btn2
  • HY-132595
    Teprasiran

    QPI-1002

    		 Small Interfering RNA (siRNA) MDM-2/p53 Cancer
    Teprasiran (QPI-1002) is a small interfering RNA that temporarily inhibits p53-mediated cell death that underlies acute kidney injury (AKI) .
    Teprasiran
  • HY-147412
    Ultevursen

    QR-421a

    		 Others Others
    Ultevursen (QR-421a) is a single-stranded RNA based oligonucleotide that is designed to skip exon 13 in the RNA with the aim to stop vision loss in people that have retinitis pigmentosa due to a mutation in exon 13 of the USH2A gene (encoding usherin). Ultevursen sequence: (P-thio)[2′-O-(2-methoxyethyl)](A-G-m 5C-m 5U-m 5U-m 5C-G-G-A-G-A-A-A-m 5U-m 5U-m 5U-A-A-A-m 5U-m 5C) .
    Ultevursen
  • HY-P99630
    Gancotamab

    MM-302

    		 EGFR Cancer
    Gancotamab (MM-302) is a HER2-targeted antibody-liposomal Doxorubicin conjugate with antitumor activity. Gancotamab encapsulates Doxorubicin to facilitate its delivery to HER2-overexpressing tumor cells .
    Gancotamab
  • HY-121309
    Doxorubicinone

    Adriamycin aglycone; Adriamycinone

    		 Endogenous Metabolite Cancer
    Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.
    Doxorubicinone
  • HY-G0022
    Doxorubicinol hydrochloride

    13-Dihydroadriamycin hydrochloride
    Doxorubicinol hydrochloride (13-Dihydroadriamycin hydrochloride) is a secondary alcohol metabolite of Doxorubicin .
    Doxorubicinol hydrochloride
  • HY-150751
    ODN TTAGGG

    ODN A151

    		 Toll-like Receptor (TLR) AIM2 Inflammation/Immunology
    ODN TTAGGG (A151), inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and cGAS antagonist. ODN TTAGGG is immunosuppressive and inhibits AIM2 inflammasome activation, as well as cGAS activation, by competing with DNA. ODN TTAGGG can be used in the study of lupus erythematosus and other related autoimmune diseases. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3' .
    ODN TTAGGG
  • HY-162324
    MX106-4C

    		Survivin Cancer
    MX106-4C is a survivin inhibitor that selectively kills ABCB1-positive colorectal cancer cells. MX106-4C can exert synergistic anticancer effects with Doxorubicin or resensitize drug-resistant ABCB1 cells to Doxorubicin .
    MX106-4C
  • HY-111954
    (+)-Erinacin A

    Erinacine A

    		 Others Neurological Disease Cancer
    (+)-Erinacin A is an anticancer compound that can be isolated from the mushroom Hericium erinaceum. (+)-Erinacin A has the capacity to trigger cancer cell death dependent on the production of reactive oxygen species (ROS). (+)-Erinacin A has anticancer and neuroprotective activity .
    (+)-Erinacin <em>A</em>
  • HY-W039943
    Acetyl-cyclosporin A aldehyde

    		Molecular Glues Cancer
    Acetyl-cyclosporin A aldehyde is an acetylated Cyclosporin A (HY-B0579) derivative with a reducing aldehyde group. Cyclosporin A is a potent calmodulin inhibitor and cyclophilin binder that can target the nuclear translocation of NF-AT and cause mitochondrial damage.
    Acetyl-cyclosporin <em>A</em> aldehyde
  • HY-12458
    Pyrindamycin A

    		DNA/RNA Synthesis Infection Cancer
    Pyrindamycin A is an antibiotic that inhibits DNA synthesis. Pyrindamycin A shows antitumor activities against murine leukemia, exhibits stronger cytotoxic activities towards murine and human tumor cell lines and especially towards doxorubicin-resistant cells, inhibits P388 and P388/ADR cells with the same IC50 of 3.9 μg/ml .
    Pyrindamycin <em>A</em>
  • HY-134428
    Arachidonoyl coenzyme A lithium

    		Endogenous Metabolite Metabolic Disease
    Arachidonoyl coenzyme A lithium is an unsaturated fatty acyl coenzyme A, formed by the condensation of the thiol group of coenzyme A with the carboxyl group of arachidonic acid .
    Arachidonoyl coenzyme <em>A</em> lithium
  • HY-147968
    Anticancer agent 74

    		Others Cancer
    Anticancer agent 74 is a moderate anticancer agent. Anticancer agent 74 has lower selectivity and cytotoxicity than doxorubicin to normal cell .
    Anticancer agent 74
  • HY-156133
    Dihydrospinosyn A aglycone

    		Others Others
    Dihydrospinosyn A aglycone (compound 2) is a derivative of spinosyn A aglycone with a hydrolyzed C9- and C17-glycosidic bond.
    Dihydrospinosyn <em>A</em> aglycone
  • HY-134424
    Propionyl coenzyme A lithium

    		Endogenous Metabolite Metabolic Disease
    Propionyl coenzyme A lithium, a coenzyme A derivative of propionic acid, is an important metabolic intermediate formed by the thioester bond between coenzyme A and propionic acid. The breakdown and production of Propionyl coenzyme A lithim is important for the metabolism of organisms .
    Propionyl coenzyme <em>A</em> lithium
  • HY-N2591
    Isocorydine

    		Endogenous Metabolite Cancer
    Isocorydine is isolated from Dicranostigma leptopodum (Maxim.) Fedde (DLF). Isocorydine combines with Doxorubicin (DOX) has a promising potential to eradicate hepatocellular carcinoma (HCC) .
    Isocorydine
  • HY-N2591A
    Isocorydine hydrochloride

    		Endogenous Metabolite Cancer
    Isocorydine hydrochloride is isolated from Dicranostigma leptopodum (Maxim.) Fedde (DLF). Isocorydine hydrochloride combines with Doxorubicin (DOX) has a promising potential to eradicate hepatocellular carcinoma (HCC) .
    Isocorydine hydrochloride
  • HY-P2004
    FFAGLDD

    		MMP Cancer
    FFAGLDD is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release .
    FFAGLDD
  • HY-157330
    P-gp inhibitor 16

    		P-glycoprotein Apoptosis Cancer
    P-gp inhibitor 16 (compound 14) is a p-glycoprotein inhibitor. P-gp inhibitor 16 significantly increases Doxorubicin-induced apoptosis and shows anticancer effects .
    P-gp inhibitor 16
  • HY-N3226
    Myricananin A

    		NO Synthase Inflammation/Immunology
    Myricananin A is a colorless needle that has inhibitory effect on iNOS .
    Myricananin <em>A</em>
  • HY-132596
    Tivanisiran

    SYL1001

    		 Small Interfering RNA (siRNA) TRP Channel Neurological Disease
    Tivanisiran (SYL1001) is a siRNA used for the study of dry eye disease. Tivanisiran was designed to silence transient receptor potential vanilloid 1 (TRPV1) .
    Tivanisiran
  • HY-132609
    Patisiran sodium

    		Small Interfering RNA (siRNA) Transthyretin (TTR) Neurological Disease
    Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis .
    Patisiran sodium
  • HY-B0006B
    (S)-Carvedilol

    (S)-BM 14190

    		 Adrenergic Receptor Cardiovascular Disease
    (S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX) .
    (S)-Carvedilol
  • HY-P2004A
    FFAGLDD TFA

    		MMP Cancer
    FFAGLDD TFA is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release .
    FFAGLDD TFA
  • HY-N3674
    Dalbergioidin

    		TGF-beta/Smad Inflammation/Immunology
    Dalbergioidin, a well-known anthocyanin, ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway. Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM .
    Dalbergioidin
  • HY-132602
    Remlarsen

    MRG-201

    		 MicroRNA Inflammation/Immunology
    Remlarsen (MRG-201), a miR-29b mimic, acts a miR-29b agonist. Remlarsen has the potential for preventiong formation of a fibrotic scar or cutaneous fibrosis .
    Remlarsen
  • HY-117175
    Pandamarilactonine A

    (+)-Pandamarilactonine A

    		 Others Others
    Pandamarilactonine A converted from Norpandamarilactonine-A of (S)-prolinol .
    Pandamarilactonine <em>A</em>
  • HY-N8488
    Anhydro-6-epiophiobolin A

    		Others Others
    Anhydro-6-epiophiobolin A, an analog of Ophiobolin A, is a potent inhibitor of photosynthesis (I50s of 6.1 and 1 mM for photosynthesis in Chlorella and Spinach, respectively) .
    Anhydro-6-epiophiobolin <em>A</em>
  • HY-150724
    ODN 1018

    1018 ISS

    		 Toll-like Receptor (TLR) Inflammation/Immunology
    ODN 1018 (1018 ISS), an oligodeoxynucleotide, is a TLR-9 agonist. ODN 1018 is also a synthetic immunostimulatory sequence that can be used as vaccine adjuvant. Sequence: 5′-TGACTGTGAACGTTCGAGATGA-3′ .
    ODN 1018
  • HY-N10563
    Coleon-U-quinone

    		P-glycoprotein Cancer
    Coleon-U-quinone is a potent P-gp inhibitor. Coleon-U-quinone can inhibit cancer cells viability and sensitize multidrug resistance cancer cells to Doxorubicin (HY-15142A) .
    Coleon-U-quinone
  • HY-154797
    N,N-Dimethyldoxorubicin

    		Others Cancer
    N,N-Dimethyldoxorubicin is a Doxorubicin (HY-15142A) analogue. N,N-Dimethyldoxorubicin shows cytotoxicity against a panel of tumor cell lines (IC50s < 0.3 μM) .
    N,N-Dimethyldoxorubicin
  • HY-N10509
    Blood-group A trisaccharide

    A-Trisaccharide

    		 Others Others
    Blood-group A trisaccharide (A-Trisaccharide) is a oligosaccharide present in the urine of blood group A secretors .
    Blood-group <em>A</em> trisaccharide
  • HY-B0006C
    (R)-Carvedilol

    (R)-BM 14190

    		 Adrenergic Receptor Cardiovascular Disease
    (R)-Carvedilol ((R)-BM 14190), the R-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (R)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX) .
    (R)-Carvedilol
  • HY-148100
    Emapticap pegol

    NOX-E36

    		 Others Inflammation/Immunology Cancer
    Emapticap pegol is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) .
    Emapticap pegol
  • HY-N8488A
    Anhydroophiobolin A

    		Others Others
    Anhydroophiobolin A is a potent inhibitor of photosynthesis with IC50s of 77 and 14 mM in the photosynthesis of chlorella and spinach, respectively. Anhydroophiobolin A is an analog of Ophiobolin A .
    Anhydroophiobolin <em>A</em>
  • HY-D1544
    Uniblue A sodium

    		Fluorescent Dye Others
    Uniblue A sodium is a reactive protein stain that can be used in the covalent pre-gel staining of the protein (Ex=594 nM) .
    Uniblue <em>A</em> sodium

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